The diagnosis of various oral lesions by taking tissue samples (biopsy) from patients and preparing slides and observing them under microscopes is done here. This department is the back bone of the many other departments of this college. Specimens from all the department are analyzed here. most advanced diagnostic equipments are installed here. Department fulfills its social obligation by doing investigation at subsidized rates. Department have state of art services including standard tissue processing & staining, immunofluorescence, flow cytometry & immunocytochemistry.

The department has 3 post graduate seats & duration of training is 3 years. Post graduates are trained in hematology, histopathology, biochemical analysis & clinical Evaluations.

Dr Ashish Mahendra is presently working as Prof. & Head in the Department of Oral Pathology. He completed his BDS in 2007 and MDS in 2011 both from Career Dental College and Hospital Lucknow.

He started his career by joining as senior lecturer in Chandra Dental College and Hospital Barabanki and working here till date and build up the department for commencement of post graduate course also.

He is Member Dental Council India, Education Counselor and Motivational Speaker. He was also an ex CRC (clinical research coordinator) in SGPGI (Sanjay Gandhi Post Graduate Institue Lucknow).

He remained as guide and co-guide in many dissertations in his academic career.

He attended many national and international conferences where he achieved awards for paper and poster presentation and also external and internal BDS & MDS examiners in various universities. He has many international publications on Oral Pathology and Forensic Odontology